Gestational trophoblastic neoplasia Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Gestational trophoblastic neoplasia from other Diseases Epidemiology and Demographics Risk Factors Screening Natural History, Complications and Prognosis Diagnosis Diagnostic Study of Choice History and Symptoms Physical Examination Laboratory Findings Electrocardiogram X-ray Echocardiography and Ultrasound CT scan MRI Other Imaging Findings Other Diagnostic Studies Treatment Medical Therapy Surgery Primary Prevention Secondary Prevention Cost-Effectiveness of Therapy Future or Investigational Therapies Case Studies Case #1 Gestational trophoblastic neoplasia staging On the Web Most recent articles Most cited articles Review articles CME Programs Powerpoint slides Images American Roentgen Ray Society Images of Gestational trophoblastic neoplasia staging All Images X-rays Echo & Ultrasound CT Images MRI Ongoing Trials at Clinical Trials.gov US National Guidelines Clearinghouse NICE Guidance FDA on Gestational trophoblastic neoplasia staging CDC on Gestational trophoblastic neoplasia staging Gestational trophoblastic neoplasia staging in the news Blogs on Gestational trophoblastic neoplasia staging Directions to Hospitals Treating Gestational trophoblastic neoplasia Risk calculators and risk factors for Gestational trophoblastic neoplasia staging Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]Sabawoon Mirwais, M.B.B.S, M.D.[3] ## Overview[edit | edit source] According to the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) cancer staging system, there are 4 stages of gestational trophoblastic neoplasia (GTN). ## Staging[edit | edit source] The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system [1] Stage | FIGO Anatomical Staging Disease confined to the uterus GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) III GTN extends to the lungs, with or without known genital tract involvement All other metastatic sites Modified WHO prognostic scoring system as adapted by Fédération Internationale de Gynécologie et d'Obstétrique (FIGO)[2] Score | 0 | 1 | 3 | 4 | | | | Age | < 40 | 40 | - | \- Antecedent pregnancy | Mole | Abortion | Term | \- Interval months from index pregnancy | < 4 | 4 - < 7 | 7 - < 13 | ≥ 13 Pre-treatment serum βhCG (iu/l) | < 103 | 103 \- < 104 | 104 \- < 105 | ≥ 105 Largest tumor size (including uterus) | - | 3 - < 5 cm | ≥ 5cm | \- Site of metastases | Lung | Spleen, Kidney | Gastrointestinal | Liver, Brain Number of metastases | - | 1 - 4 | 5 - 8 | > 8 Previous failed chemotherapy | - | - | 1 drug | 2 or more drugs ## References[edit | edit source] 1. ↑ Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015 2. ↑ Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC, Pecorelli S (October 2003). "Gestational trophoblastic neoplasia, FIGO 2000 staging and classification". Int J Gynaecol Obstet. 83 Suppl 1: 175–7. PMID 14763174.