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Vaccine might refer to:

A US sailor receiving a flu vaccine

* Anti-vaccination movement — anti-vaccination quacks and those that believe them
* Autism omnibus trial — the trial with plaintiffs trying to get money by claiming damages from the disproved claim that vaccines induced autism
* Herd immunity — the idea that when a certain percentage of a population is vaccinated, those within the population who are not vaccinated are protected from the disease
* HPV vaccine — the needlessly controversial vaccine for a sexually transmitted disease
* HPV vaccine FAQ rebuttal — point-by-point rebuttal of Conservapedia's HPV vaccine FAQ
* Hepatitis B vaccine — the not-as-controversial hepatitis vaccine
* COVID-19 vaccine — the coronavirus vaccine
* Flu shot — basic idea and principles
* Smallpox — smallpox and its vaccine
* Vaccination Information Network — a rabid anti-vaccination organization