Tamsulosin detailed informationClinical data

Pregnancy
category|

* B2 (Aust)

Routes of
administration| oral
ATC code|

* G04CA02 (WHO)

Legal status
Legal status|

* Schedule 4 (Aust)
POM (UK)

Pharmacokinetic data
Bioavailability| 100% (oral)
Metabolism| hepatic
Elimination half-life| 9–13 hours
Excretion| 76% renal
Identifiers

IUPAC name

* (R)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-
2-methoxybenzenesulfonamide

CAS Number|

* 106133-20-4

PubChem CID|

* 129211

DrugBank|

* APRD00036

E number| {{#property:P628}}
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Chemical and physical data
Formula| C20H28N2O5S
Molar mass| 408.51

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## For patient information, click here[edit | edit source]

## Overview[edit | edit source]

Tamsulosin (rINN) (Template:PronEng) is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL. As of 2006, tamsulosin hydrochloride extended-release tablets are marketed under the trade name Flomaxtra. It was formerly marketed as modified-release capsules under the trade name Flomax.

## Clinical use[edit | edit source]

Main article: Alpha blocker

## Adverse effects[edit | edit source]

Two ADRs (Adverse Drug Reactions) have been reported:

* Immunologic: It contains a sulfa moiety, thus causing typical reactions to sulfa drugs.
* Ophthalmologic: Patients taking tamsulosin are prone to a complication known as floppy iris syndrome during cataract surgery. Adverse outcomes of the surgery are greatly reduced by the surgeon's prior knowledge of the patient's history with this drug, and thus having the option of alternative techniques. [2]

Tamsulosin has also affected the sexual function in men. Tamsulosin can cause males to experience retrograde ejaculation.

## Clinical comparison[edit | edit source]

Although prostate specific, it does not have the prostate apoptotic effects of other alpha-blockers such as doxazosin and terazosin.

## External links[edit | edit source]

* Tamsulosin (systemic) – information from USP DI Advice for the Patient
* Flomax (drugs.com) – U.S. product information
* Flomax (Official Site) – Official Site

* v
* t
* e

Urologicals (G04)

Acidifiers|

Ammonium chloride, Calcium chloride

Urinary antispasmodics (primarily antimuscarinics)|

Darifenacin, Emepronium, Fesoterodine, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium

For erectile dysfunction|

prostaglandins: Alprostadil

PDE5 inhibitors: Avanafil \- Sildenafil \- Tadalafil \- Udenafil \- Vardenafil

alpha blockers: Moxisylyte \- Phentolamine \- Yohimbine

others: Apomorphine \- Papaverine

Other urologicals|

Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Pentosan polysulfate, Phenazopyridine, Phenyl salicylate, Succinimide

For benign prostatic hypertrophy|

5α-reductase inhibitors: Dutasteride, Finasteride

Alpha blockers: Alfuzosin, Doxazosin, Silodosin, Tamsulosin, Terazosin

Herbals: Pygeum africanum, Serenoa repens

de:Tamsulosin

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