He is Professor Emeritus and Principal Research Associate at the UCL Queen Square Institute of Neurology, Honorary Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, and was the National Director for Dementia Research for the National Institute of Health Research (NIHR) in the UK.
He was the editor of the Journal of Neurology, Neurosurgery and Psychiatry, President of the Association of British Neurologists, Director of the NIHR Clinical Research Network for Dementia and Neurodegenerative Diseases, and Director of the NIHR Queen Square Dementia Biomedical Research Unit.
His collaborative work in identifying and characterising a large collection of familial cases of Alzheimer’s disease contributed to the discovery of mutations in the amyloid precursor protein gene[1],[2].
His recent research focuses on general cognitive impairment in systemic disease and multimorbidity including development of the Cognitive Footprint concept, which he co-authored in 2015[3].