Meglumine antimoniate

Clinical data
Other names| Meglumine antimonate
AHFS/Drugs.com| Micromedex Detailed Consumer Information
ATC code|

* P01CB01 (WHO) QP51AB01 (WHO)

Identifiers

IUPAC name

* Hydroxy-dioxostiborane; (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol

CAS Number|

* 133-51-7 N

PubChem CID|

* 64953

ChemSpider|

* 58479 Y

UNII|

* 75G4TW236W

ChEMBL|

* ChEMBL239129 Y

NIAID ChemDB|

* 008733

Chemical and physical data
Formula| Variable
Molar mass| Variable
3D model (JSmol)|

* Interactive image

SMILES

* O=[Sb](=O)O.O[C@@H]([C@@H](O)[C@H](O)[C@@H](O)CNC)CO

InChI

* InChI=1S/C7H17NO5.H2O.2O.Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;;;;/h4-13H,2-3H2,1H3;1H2;;;/q;;;;+1/p-1/t4-,5+,6+,7+;;;;/m0..../s1 Y

* Key:XOGYVDXPYVPAAQ-SESJOKTNSA-M Y

NY (what is this?) (verify)

Meglumine antimoniate is a medicine used to treat leishmaniasis.[1] This includes visceral, mucocutaneous, and cutaneous leishmaniasis.[1] It is given by injection into a muscle or into the area infected.[1]

Side effects include loss of appetite, nausea, abdominal pain, cough, feeling tired, muscle pain, irregular heartbeat, and kidney problems.[1] It should not be used in people with significant heart, liver, or kidney problems.[1] It is not recommended during breastfeeding.[1] It belongs to a group of medications known as the pentavalent antimonials.[1]

Meglumine antimoniate came into medical use in 1946.[2] It is on the World Health Organization's List of Essential Medicines.[3] It is available in Southern Europe and Latin America but not the United States.[4][5]

## Contents

* 1 Society and culture
* 2 See also
* 3 References
* 4 External links

## Society and culture

It is manufactured by Aventis[6] and sold as Glucantime in France , and Glucantim in Italy.

## See also

* Meglumine

## References

1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 WHO Model Formulary 2008. World Health Organization. 2009. p. 183. ISBN 9789241547659.
2. ↑ Sneader, Walter (2005) (in en). Drug Discovery: A History. John Wiley & Sons. p. 59. ISBN 9780470015520. https://books.google.com/books?id=jglFsz5EJR8C&pg=PA59.
3. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
4. ↑ Bope, Edward T.; Kellerman, Rick D.; Rakel, Robert E. (2010) (in en). Conn's Current Therapy 2011: Expert Consult. Elsevier Health Sciences. p. 95. ISBN 978-1437735727. https://books.google.com/books?id=pxnKBrfwTFYC&pg=PT128.
5. ↑ Gorbach, Sherwood L.; Bartlett, John G.; Blacklow, Neil R. (2004) (in en). Infectious Diseases. Lippincott Williams & Wilkins. p. 355. ISBN 9780781733717. https://books.google.com/books?id=91altE1evAsC&pg=PA355.
6. ↑ Aventis press release , 15 April 2005. (in German)

## External links

* "Meglumine antimoniate". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/meglumine antimoniate.

* v
* t
* e

Antiparasitics – antiprotozoal agents – Excavata antiparasitics (P01)

Discicristata|

| Trypanosomiasis|

* African trypanosomiasis: ornithine]] (Eflornithine#)
* arsenical (Melarsoprol#)
* benzamidine (Pentamidine#)
* naphthalenesulfonate (Suramin#)

* nitroimidazole (Fexinidazole†)

Chagas disease: nitroimidazole]] (Benznidazole#)

* nitrofuran (Nifurtimox#)

|

Leishmaniasis|

* macrolide (Amphotericin B#)

Pentavalent antimonials (Meglumine antimoniate#, Sodium stibogluconate)

* benzamidine (Pentamidine#)
* phosphorylcholine (Miltefosine)
* neomycin (Paromomycin)

PAM|

* macrolide (Amphotericin B)

Trichozoa|

| Giardiasis|

* nitroimidazole (Metronidazole#, Tinidazole)
* benzimidazole (Albendazole)

* thiazolide (Nitazoxanide)
* nitrofuran (Furazolidone)

* aminoacridine (Quinacrine)

|

Trichomoniasis|

* nitroimidazole (Carnidazole, Metronidazole#, Tinidazole)

Dientamoebiasis|

* nitroimidazole (Metronidazole
* Secnidazole)

* oxyquinoline (Iodoquinol)
* tetracycline (Doxycycline)
* neomycin (Paromomycin)

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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