AIM-HIGH was a multi-center clinical trial related to the prophylactic treatment coronary artery disease involving some 90 sites in the United States and Canada , which was conducted between 2006 and 2012 and involved 3,414 volunteers [1]. AIM-HIGH was an acronym for Atherothrombosis Intervention in Metabolic Syndrome with low HDL/HIGH Triglycerides trial[2] ## Contents * 1 Description * 2 Results * 3 References ## Description The trial was designed to test whether adding high dose, extended-release niacin to simvastatin may be a better than statin therapy alone in reducing long-term cardiovascular events. The participants, who all had a history of cardiovascular disease, were selected according to the following profile: [3] * LDL cholesterol was controlled * HDL cholesterol levels were low * triglycerides levels were high ## Results The trial was stopped early because there was a demonstrable lack of efficacy for this intervention. The addition of high dose, extended release niacin to a statin did increase HDL cholesterol, as expected, but did not reduce cardiovascular events. The analysis also showed that there was little to no probability that adding high-dose, extended release niacin to statin treatment would show a benefit even if the study continued to its originally planned completion. ## References 1. ↑ National Heart Lung & Blood Institute (USA) Questions and Answers: AIM-HIGH Study, May 26, 2011 2. ↑ Healio Cardiology Review of AIM-HIGH trial 3. ↑ New England Journal of Medicine 2018-09-17 pp 2255 - 2267 * v * t * e Cardiovascular disease (vessels) (I70–I99, 440–456) Arteries, arterioles and capillaries| | Inflammation| * Arteritis * Aortitis * Buerger's disease | Peripheral artery disease| | Arteriosclerosis| * Atherosclerosis * Foam cell * Fatty streak * Atheroma * Intermittent claudication * Critical limb ischemia * Monckeberg's arteriosclerosis * Arteriolosclerosis * Hyaline * Hyperplastic * Cholesterol * LDL * Oxycholesterol * Trans fat | Stenosis| * Carotid artery stenosis * Renal artery stenosis Other| * Aortoiliac occlusive disease * Degos disease * Erythromelalgia * Fibromuscular dysplasia * Raynaud's phenomenon Aneurysm / dissection / pseudoaneurysm| * torso: Aortic aneurysm * Abdominal aortic aneurysm * Thoracic aortic aneurysm * Aneurysm of sinus of Valsalva * Aortic dissection * Aortic rupture * Coronary artery aneurysm * head / neck * Intracranial aneurysm * Intracranial berry aneurysm * Carotid artery dissection * Vertebral artery dissection * Familial aortic dissection Vascular malformation| * Arteriovenous fistula * Arteriovenous malformation * Telangiectasia * Hereditary hemorrhagic telangiectasia Vascular nevus| * Cherry hemangioma * Halo nevus * Spider angioma Veins| | Inflammation| * Phlebitis | Venous thrombosis / Thrombophlebitis| * primarily lower limb * Deep vein thrombosis * abdomen * Hepatic veno-occlusive disease * Budd–Chiari syndrome * May–Thurner syndrome * Portal vein thrombosis * Renal vein thrombosis * upper limb / torso * Mondor's disease * Paget–Schroetter disease * head * Cerebral venous sinus thrombosis * Post-thrombotic syndrome Varicose veins| * Gastric varices * Portacaval anastomosis * Caput medusae * Esophageal varices * Hemorrhoid * Varicocele Other| * Chronic venous insufficiency * Chronic cerebrospinal venous insufficiency * Superior vena cava syndrome * Inferior vena cava syndrome * Venous ulcer Arteries or veins| * Angiopathy * Macroangiopathy * Microangiopathy * Embolism * Pulmonary embolism * Cholesterol embolism * Paradoxical embolism * Thrombosis * Vasculitis Blood pressure| | Hypertension| * Hypertensive heart disease * Hypertensive emergency * Hypertensive nephropathy * Essential hypertension * Secondary hypertension * Renovascular hypertension * Benign hypertension * Pulmonary hypertension * Systolic hypertension * White coat hypertension | Hypotension| * Orthostatic hypotension 0.00 (0 votes) | Retrieved from "https://handwiki.orghttps://handwiki.org/wiki/index.php?title=Medicine:AIM-HIGH_trial&oldid=2129432" *[v]: View this template *[t]: Discuss this template *[e]: Edit this template