cis-2-enoyl-CoA reductase (NADPH)

Identifiers
EC no.| 1.3.1.37
CAS no.| 72841-00-0
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a cis-2-enoyl-CoA reductase (NADPH) (EC 1.3.1.37) is an enzyme that catalyzes the chemical reaction

acyl-CoA + NADP+ ⇌ {\displaystyle \rightleftharpoons } cis-2,3-dehydroacyl-CoA + NADPH + H+

Thus, the two substrates of this enzyme are acyl-CoA and NADP+, whereas its 3 products are cis-2,3-dehydroacyl-CoA, NADPH, and H+.

## Nomenclature[edit]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ cis-2-oxidoreductase. Other names in common use include NADPH-dependent cis-enoyl-CoA reductase, reductase, cis-2-enoyl coenzyme A, cis-2-enoyl-coenzyme A reductase, and cis-2-enoyl-CoA reductase (NADPH).

## References[edit]

## Further reading[edit]

* Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H (November 1982). "Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli". Journal of Biochemistry. 92 (5): 1649–54. PMID 6759504.

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Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor|

* Enoyl-acyl carrier protein reductase/Enoyl ACP reductase
* 7-Dehydrocholesterol reductase
* Biliverdin reductase
* 2,4 Dienoyl-CoA reductase
* Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor|

* Dihydroorotate dehydrogenase
* Coproporphyrinogen III oxidase
* Protoporphyrinogen oxidase
* Bilirubin oxidase
* Acyl-CoA oxidase
* Dihydrouracil oxidase
* Tetrahydroberberine oxidase
* Secologanin synthase
* Tryptophan alpha,beta-oxidase
* Pyrroloquinoline-quinone synthase
* L-galactonolactone oxidase

1.3.5: Quinone|

* Succinate dehydrogenase
* SDHA
* SDHB
* SDHC
* SDHD

1.3.99: Other acceptors|

* Fumarate reductase
* Butyryl-CoA dehydrogenase
* Acyl CoA dehydrogenase
* ACADSB
* ACADS
* 5α-reductase
* SRD5A1
* SRD5A2
* SRD5A3
* Glutaryl-CoA dehydrogenase
* Isovaleryl coenzyme A dehydrogenase
* 3-oxo-5beta-steroid 4-dehydrogenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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