| Haplogroup JT | |
|---|---|
| Possible time of origin | 50,300 YBP |
| Possible place of origin | Southwest Asia |
| Ancestor | R2'JT |
| Descendants | J, T |
| Defining mutations | 11251, 15452A, 16126[1] |
Haplogroup JT is a human mitochondrial DNA (mtDNA) haplogroup.
Origin[edit]
Haplogroup JT is descended from the macro-haplogroup R. It is the ancestral clade to the mitochondrial haplogroups J and T.
JT (predominantly J) was found among the ancient Etruscans.[2] The haplogroup has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[3] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroup H subclade H14b1 (1/9; 11%).[4]
Subclades[edit]
Tree[edit]
This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.
Health[edit]
Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson's disease[5] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.[6][7]
See also[edit]
|
Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups | |||||||||||||||||||||||||||||||||||||||
| Mitochondrial Eve (L) | |||||||||||||||||||||||||||||||||||||||
| L0 | L1–6 | ||||||||||||||||||||||||||||||||||||||
| L1 | L2 | L3 | L4 | L5 | L6 | ||||||||||||||||||||||||||||||||||
| M | N | ||||||||||||||||||||||||||||||||||||||
| CZ | D | E | G | Q | O | A | S | R | I | W | X | Y | |||||||||||||||||||||||||||
| C | Z | B | F | R0 | pre-JT | P | U | ||||||||||||||||||||||||||||||||
| HV | JT | K | |||||||||||||||||||||||||||||||||||||
| H | V | J | T | ||||||||||||||||||||||||||||||||||||
References[edit]
- ^ a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457.
- ^ "We Are Not Our Ancestors".
- ^ Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014). "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14: 109. doi:10.1186/1471-2148-14-109. PMC 4062890. PMID 24885141.
- ^ Kefi, Rym; et al. (2016). "On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations". Mitochondrial DNA Part A. 29 (1): 147–157. doi:10.1080/24701394.2016.1258406. PMID 28034339. S2CID 4490910.
- ^ Marom S, Friger M, Mishmar D. MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association. Sci Rep. 2017 Feb 23;7:43449. doi: 10.1038/srep43449. PMID 28230165; PMCID: PMC5322532.
- ^ Rebeca Martín-Jiménez, Olivier Lurette, and Etienne Hebert-Chatelain.DNA and Cell Biology.Aug 2020.1421-1430.http://doi.org/10.1089/dna.2020.5398
- ^ Mitochondrion. 2019 May; 46: 307–312.doi: 10.1016/j.mito.2018.07.008
External links[edit]
- General
- Ian Logan's Mitochondrial DNA Site
- Mannis van Oven's Phylotree
  | This bioinformatics-related article is a stub. You can help Wikipedia by expanding it. |
 | This genetics article is a stub. You can help Wikipedia by expanding it. |