Tirilazad

Clinical data
Other names| (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
ATC code|

* N07XX01 (WHO)

Identifiers

IUPAC name

* (16α)-21-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]-16-methylpregna-1,4,9(11)-triene-3,20-dione

CAS Number|

* 110101-66-1 N

PubChem CID|

* 104903

ChemSpider|

* 94673 Y

UNII|

* YD064E883I

KEGG|

* D08606 Y

ChEMBL|

* ChEMBL1630578 N

Chemical and physical data
Formula| C38H52N6O2
Molar mass| 624.874 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* O=C(CN4CCN(c2nc(nc(N1CCCC1)c2)N3CCCC3)CC4)[C@H]6[C@H](C)C[C@H]5[C@H]8C(=C/C[C@@]56C)\\[C@]/7(/C=C\C(=O)\C=C\7CC8)C

InChI

* InChI=1S/C38H52N6O2/c1-26-22-31-29-9-8-27-23-28(45)10-12-37(27,2)30(29)11-13-38(31,3)35(26)32(46)25-41-18-20-43(21-19-41)34-24-33(42-14-4-5-15-42)39-36(40-34)44-16-6-7-17-44/h10-12,23-24,26,29,31,35H,4-9,13-22,25H2,1-3H3/t26-,29-,31+,35-,37+,38+/m1/s1 Y

* Key:RBKASMJPSJDQKY-RBFSKHHSSA-N Y

NY (what is this?) (verify)

Tirilazad is a drug that has been proposed to treat acute ischaemic stroke. When tested on animal models, tirilazad protects brain tissue, and reduces brain damage. However, the drug fails to treat, and even worsens a stroke when studied on a human being.[1]

## Usage in treatment of stroke

Tirilazad currently has no usage in the clinical treatment of stroke.

## References

1. ↑ "Tirilazad for acute ischaemic stroke". http://www.cochrane.org/reviews/en/ab002087.html.

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* e

Other nervous system drugs (N07X)

Stroke|

* Tirilazad

ALS|

* Riluzole
* Xaliproden
* Arimoclomol§
* Mecasermin rinfabate†

Other|

* Hydroxybutyric acid
* Amifampridine
* Fampridine
* Inotersen
* Tafamidis
* hyperkinesis
* Deutetrabenazine
* Tetrabenazine
* Valbenazine

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

* v
* t
* e

Piperazines

Simple piperazines
(no additional rings)|

* 1-Cyclohexylpiperazine
* Aminoethylpiperazine
* Diethylcarbamazine
* HEPPS
* Midafotel
* Piperazine
* PIPES

Phenylpiperazines|

* Acaprazine
* Antrafenine
* Aripiprazole
* Batoprazine
* Bifeprunox
* BRL-15,572
* Ciprofloxacin
* CSP-2503
* Dapiprazole
* DCPP
* DMPP
* Diphenylpiperazine
* Dropropizine
* EGIS-12,233
* Elopiprazole
* Eltoprazine
* Enpiprazole
* Ensaculin
* Etoperidone
* Flesinoxan
* Fluanisone
* Flibanserin
* Fluprazine
* Itraconazole
* Ketoconazole
* Levodropropizine
* Lorpiprazole
* mCPP
* Mefway
* MeOPP
* Mepiprazole
* Naftopidil
* Naluzotan
* Naphthylpiperazine
* Nefazodone
* Niaprazine
* Oxypertine
* Pardoprunox
* pCPP
* pFPP
* Posaconazole
* S-14,506
* S-14,671
* S-15,535
* SB-258,585
* SB-271,046
* SB-357,134
* SB-399,885
* Sonepiprazole
* TFMPP
* Tolpiprazole
* Trazodone
* Urapidil
* Vesnarinone
* Vilazodone
* Vortioxetine
* WAY-100,135
* WAY-100,635

Benzylpiperazines|

* 2C-B-BZP
* Befuraline
* Bifeprunox
* Buclizine
* BZP
* Chlorbenzoxamine
* DBZP
* Fipexide
* Imatinib
* MBZP
* MDBZP
* Meclozine
* Methoxypiperamide
* Piberaline
* Piribedil
* Sunifiram
* Trimetazidine
* Vesnarinone

Diphenylalkylpiperazines
(benzhydrylalkylpiperazines)|

* AD-1211
* Almitrine
* Amperozide
* BRL-15,572
* Buclizine
* BW373U86
* Cetirizine
* Chlorbenzoxamine
* Chlorcyclizine
* Cinnarizine
* Clocinizine
* Cyclizine
* DBL-583
* Diphenpipenol
* Diphenylmethylpiperazine
* Dotarizine
* DPI-221
* DPI-287
* DPI-3290
* GBR-12,783
* GBR-12,935
* GBR-13,069
* GBR-13,098
* GBR-13,119
* Hydroxyzine
* Lidoflazine
* Manidipine
* Meclozine
* MT-45
* Oxatomide
* SNC-80
* Vanoxerine

Pyrimidinylpiperazines|

* Buspirone
* Dasatinib
* Eptapirone
* Gepirone
* Ipsapirone
* Piribedil
* Prazitone
* Pyrimidinylpiperazine
* Revospirone
* Tandospirone
* Tirilazad
* Trimazosin
* Umespirone
* Zalospirone

Pyridinylpiperazines|

* Atevirdine
* Azaperone
* Delavirdine
* Mirtazapine
* Pyridinylpiperazine

Benzo(iso)thiazolylpiperazines|

* Lurasidone
* Perospirone
* Revospirone
* Tiospirone
* Ziprasidone

Tricyclics
(piperazine attached via side chain)|

* Amoxapine
* Clopenthixol
* Clorotepine
* Clozapine
* Cyanothepin
* Doclothepin
* Docloxythepin
* Flupentixol
* Fluphenazine
* Isofloxythepin
* Loxapine
* Meperathiepin
* Metitepine
* Octomethothepin
* Olanzapine
* Opipramol
* Oxyclothepin
* Oxyprothepin
* Peradithiepin
* Perathiepin
* Perazine
* Perphenazine
* Pirenzepine
* Prochlorperazine
* Thiethylperazine
* Thiothixene
* Trifluoperazine
* Trifluthepin
* Zuclopenthixol

Others/Uncategorized|

* 6-Nitroquipazine
* Azimilide
* Cinepazet
* Cinepazic acid
* Cinepazide
* Cyclohexylpiperazine
* EGIS-7625
* Hexocyclium
* Indinavir
* JNJ-7777120
* Lodenafil
* Mirodenafil
* PB-28
* Quipazine
* Ranolazine
* SA-4503
* Sildenafil
* Tadalafil
* Vardenafil
* VUF-6002
* WY-46824
* Zipeprol

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Original source: https://en.wikipedia.org/wiki/Tirilazad. Read more

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