Troponin WikiDoc Resources for Troponin I Articles Most recent articles on Troponin I Most cited articles on Troponin I Review articles on Troponin I Articles on Troponin I in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Troponin I Images of Troponin I Photos of Troponin I Podcasts & MP3s on Troponin I Videos on Troponin I Evidence Based Medicine Cochrane Collaboration on Troponin I Bandolier on Troponin I TRIP on Troponin I Clinical Trials Ongoing Trials on Troponin I at Clinical Trials.gov Trial results on Troponin I Clinical Trials on Troponin I at Google Guidelines / Policies / Govt US National Guidelines Clearinghouse on Troponin I NICE Guidance on Troponin I NHS PRODIGY Guidance FDA on Troponin I CDC on Troponin I Books Books on Troponin I News Troponin I in the news Be alerted to news on Troponin I News trends on Troponin I Commentary Blogs on Troponin I Definitions Definitions of Troponin I Patient Resources / Community Patient resources on Troponin I Discussion groups on Troponin I Patient Handouts on Troponin I Directions to Hospitals Treating Troponin I Risk calculators and risk factors for Troponin I Healthcare Provider Resources Symptoms of Troponin I Causes & Risk Factors for Troponin I Diagnostic studies for Troponin I Treatment of Troponin I Continuing Medical Education (CME) CME Programs on Troponin I International Troponin I en Espanol Troponin I en Francais Business Troponin I in the Marketplace Patents on Troponin I Experimental / Informatics List of terms related to Troponin I Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2] ## Overview[edit | edit source] Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place. The letter I is given due to its inhibitory character. The tissue specific subtypes are: * Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042) * Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043) * Cardiac troponin I, TNNI3 (19q13.4, 191044) ## External links[edit | edit source] * Troponin+I at the US National Library of Medicine Medical Subject Headings (MeSH) * v * t * e Muscle tissue Smooth muscle| * Calmodulin * Vascular smooth muscle Striated muscle| | Skeletal muscle| | Costamere/ DAPC| | Membrane/ extracellular| | DAP:| * Sarcoglycan * SGCA * SGCB * SGCD * SGCE * SGCG * SGCZ * Dystroglycan | * Sarcospan * Laminin, alpha 2 Intracellular| * Dystrophin * Dystrobrevin * A * B * Syntrophin * A * B1 * B2 * G1 * G2 * Syncoilin * Dysbindin * Synemin/desmuslin related:| * NOS1 * Caveolin 3 Sarcomere/ (a, i, and h bands; z and m lines)| * Myofilament * thin filament/actin * thick filament/myosin * elastic filament/titin * nebulin * Tropomyosin * Troponin * T * C * I Connective tissue| * Epimysium * Fascicle * Perimysium * Endomysium * Connective tissue in skeletal muscle General| * Neuromuscular junction * Motor unit * Muscle spindle * Excitation–contraction coupling * Sliding filament mechanism Cardiac muscle| * Myocardium * Intercalated disc * Nebulette Both| | Fiber| * Muscle fiber * intrafusal * extrafusal * Myofibril * Microfilament/Myofilament * Sarcomere | Cells| * Myoblast/Myocyte * Myosatellite cell Other| * Desmin * Sarcoplasm * Sarcolemma * T-tubule * Sarcoplasmic reticulum Other/ ungrouped| * Myotilin * Telethonin * Dysferlin * Fukutin * Fukutin-related protein * v * t * e Electrocardiography Overview| History of the EKG • EKG interpretation basics • Normal sinus rhythm EKG Complexes| P wave • QRS complex • ST Segment • T wave • T wave alternans • Tombstone T wave • U wave Osborn wave • H wave • K wave • Delta wave NSSTW changes EKG Intervals| PR Interval • QRS Interval • ST Interval • QT Interval Conduction System & Bradycardia| Cardiac pacemaker • SA node • AV node• Bundle of His • Purkinje fibers • Sinus bradycardia • First Degree AV Block • Second Degree AV Block • Complete or Third-Degree AV Block • Concealed conduction • AV Junctional Rhythms • LBBB • LAHB • LPHB • RBBB • Trifascicular block Atrial Arrhythmias| Sinus tachycardia • Premature Atrial Contractions (PACs) • Ectopic Atrial Rhythm • Paroxysmal Atrial Tachycardia (PAT) • Paroxysmal Atrial Tachycardia (PAT) with Block • Multifocal Atrial Tachycardia (MAT) • Atrial Flutter • Atrial Fibrillation • Wandering atrial pacemaker Ventricular Arrhythmias| Differential Diagnosis of Tachycardia with a Wide QRS Complex • Accelerated Idioventricular Rhythm • Ventricular Parasystole • Premature Ventricular Contractions (PVCs) • Ventricular tachycardia • Ventricular Fibrillation • Sudden cardiac death EKG Abnormalities in Disease States| Hypertrophy & Dilatation • Right atrial enlargement • Left atrial enlargement • Biatrial enlargement • Left Ventricular Hypertrophy • Right Ventricular Hypertrophy • Biventricular Hypertrophy • Acute myocardial infarction • NSTEMI • STEMI • Tombstone ST elevation • Right ventricular myocardial infarction • Atrial infarction Pre-excitation Syndromes • Wolff-Parkinson-White Syndrome • Lown Ganong Levine Syndrome • Mahaim Type Preexcitation Cardiomyopathies • Arrhythmogenic Right Ventricular Dysplasia • Dilated Cardiomyopathy • Hypertrophic Cardiomyopathy Drug Effects on the EKG • Adenosine • β-blockers • Digitalis • Quinidine • Procainamide • Disopyramide • Lidocaine • Tocainide and Mexiletine • Phenytoin • Encainide, Flecainide and Propafenone • Amiodarone • Bretylium • Ca Channel Blockers • Phenothiazines • Tricyclic Antidepressants • Lithium Congenital Heart Disease • Dextrocardia • Atrial Septal Defect • Ventricular Septal Defect • Tetralogy of Fallot • Conjoined Twins or Siamese Twins • Congenital heart block Electrolyte Disturbances • Hyperkalemia • Hypokalemia • Hypercalcemia • Hypocalcemia • Nonspecific Changes Other Heart Diseases • Pericarditis • Myocarditis • Tamponade • Heart Transplantation • Sick Sinus Syndrome • Long QT Syndrome Inherited Disease • Brugada Syndrome Systemic Diseases • CNS Disease • Cardiac Tumors Heart Transplantation • EKG Changes in patient with Heart Transplantation Exogenous Effects • Hypothermia • Chest Trauma • Insect Bites • Electric Injuries Technical Issues and Potential Errors in Interpretation| Artifacts • Lead Placement Errors • The EKG in a Patient with a Pacemaker • EKG in athletes * v * t * e Cardiovascular disease (heart) Ischaemic| | Coronary disease| * Coronary artery disease (CAD) * Coronary artery aneurysm * Spontaneous coronary artery dissection (SCAD) * Coronary thrombosis * Coronary vasospasm * Myocardial bridge | Active ischemia| * Angina pectoris * Prinzmetal's angina * Stable angina * Acute coronary syndrome * Myocardial infarction * Unstable angina Sequelae| * hours * Hibernating myocardium * Myocardial stunning * days * Myocardial rupture * weeks * Aneurysm of heart / Ventricular aneurysm * Dressler syndrome Layers| | Pericardium| * Pericarditis * Acute * Chronic / Constrictive * Pericardial effusion * Cardiac tamponade * Hemopericardium | Myocardium| * Myocarditis * Chagas disease * Cardiomyopathy * Dilated * Alcoholic * Hypertrophic * Tachycardia-induced * Restrictive * Loeffler endocarditis * Cardiac amyloidosis * Endocardial fibroelastosis * Arrhythmogenic right ventricular dysplasia Endocardium / valves| | Endocarditis| * infective endocarditis * Subacute bacterial endocarditis * non-infective endocarditis * Libman–Sacks endocarditis * Nonbacterial thrombotic endocarditis | Valves| * mitral * regurgitation * prolapse * stenosis * aortic * stenosis * insufficiency * tricuspid * stenosis * insufficiency * pulmonary * stenosis * insufficiency Conduction / arrhythmia| | Bradycardia| * Sinus bradycardia * Sick sinus syndrome * Heart block: Sinoatrial * AV * 1° * 2° * 3° * Intraventricular * Bundle branch block * Right * Left * Left anterior fascicle * Left posterior fascicle * Bifascicular * Trifascicular * Adams–Stokes syndrome | Tachycardia (paroxysmal and sinus)| | Supraventricular| * Atrial * Multifocal * Junctional * AV nodal reentrant * Junctional ectopic | Ventricular| * Accelerated idioventricular rhythm * Catecholaminergic polymorphic * Torsades de pointes Premature contraction| * Atrial * Junctional * Ventricular Pre-excitation syndrome| * Lown–Ganong–Levine * Wolff–Parkinson–White Flutter / fibrillation| * Atrial flutter * Ventricular flutter * Atrial fibrillation * Familial * Ventricular fibrillation Pacemaker| * Ectopic pacemaker / Ectopic beat * Multifocal atrial tachycardia * Pacemaker syndrome * Parasystole * Wandering atrial pacemaker Long QT syndrome| * Andersen–Tawil * Jervell and Lange-Nielsen * Romano–Ward Cardiac arrest| * Sudden cardiac death * Asystole * Pulseless electrical activity * Sinoatrial arrest Other / ungrouped| * hexaxial reference system * Right axis deviation * Left axis deviation * QT * Short QT syndrome * T * T wave alternans * ST * Osborn wave * ST elevation * ST depression * Strain pattern Cardiomegaly| * Ventricular hypertrophy * Left * Right / Cor pulmonale * Atrial enlargement * Left * Right * Athletic heart syndrome Other| * Cardiac fibrosis * Heart failure * Diastolic heart failure * Cardiac asthma * Rheumatic fever Template:WikiDoc Sources *[v]: View this template *[t]: Discuss this template *[e]: Edit this template