VALUE_ERROR (nil) Identifiers Aliases| External IDs| GeneCards: [1] Orthologs Species| Human| Mouse Entrez| | n/a n/a Ensembl| | n/a n/a UniProt| | n/a n/a RefSeq (mRNA)| | n/a n/a RefSeq (protein)| | n/a n/a Location (UCSC)| n/a| n/a PubMed search| n/a| n/a Wikidata | View/Edit Human| | Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.[1][2] ## Contents * 1 Function * 2 Interactions * 3 References * 4 Further reading ## Function[edit | edit source] The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.[2] ## Interactions[edit | edit source] MAP3K13 has been shown to interact with PRDX3.[3] ## References[edit | edit source] 1. ↑ Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328. 2. ↑ 2.0 2.1 "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13". 3. ↑ Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477. ## Further reading[edit | edit source] * Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477. * Ikeda A, Sakuma H, Masaki M, Kozutsumi Y, Oka S, Inazawa J, Kawasaki T (2002). "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene". J. Biochem. Mol. Biol. Biophys. 6 (2): 113–7. doi:10.1080/10258140290027243. PMID 12186766. * Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem. 130 (6): 773–81. doi:10.1093/oxfordjournals.jbchem.a003048. PMID 11726277. * Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T (2001). "Identification and characterization of functional domains in a mixed lineage kinase LZK". FEBS Lett. 488 (3): 190–5. doi:10.1016/S0014-5793(00)02432-7. PMID 11163770. * Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451. * v * t * e Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12) Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20) | Non-specific serine/threonine protein kinases (EC 2.7.11.1)| * LATS1 * LATS2 * MAST1 * MAST2 * STK38 * STK38L * CIT * ROCK1 * SGK * SGK2 * SGK3 * Protein kinase B * AKT1 * AKT2 * AKT3 * Ataxia telangiectasia mutated * mTOR * EIF-2 kinases * PKR * HRI * EIF2AK3 * EIF2AK4 * Wee1 * WEE1 | Pyruvate dehydrogenase kinase (EC 2.7.11.2)| * PDK1 * PDK2 * PDK3 * PDK4 Dephospho-(reductase kinase) kinase (EC 2.7.11.3)| * AMP-activated protein kinase α * PRKAA1 * PRKAA2 * β * PRKAB1 * PRKAB2 * γ * PRKAG1 * PRKAG2 * PRKAG3 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)| * BCKDK * BCKDHA * BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)| * IDH2 * IDH3A * IDH3B * IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)| * STK4 Myosin-heavy-chain kinase (EC 2.7.11.7)| * Aurora kinase * Aurora A kinase * Aurora B kinase * Aurora C kinase Fas-activated serine/threonine kinase (EC 2.7.11.8)| * FASTK * STK10 Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)| * - IκB kinase (EC 2.7.11.10)| * CHUK * IKK2 * TBK1 * IKBKE * IKBKG * IKBKAP cAMP-dependent protein kinase (EC 2.7.11.11)| * Protein kinase A * PRKACG * PRKACB * PRKACA * PRKY cGMP-dependent protein kinase (EC 2.7.11.12)| * Protein kinase G * PRKG1 Protein kinase C (EC 2.7.11.13)| * Protein kinase C * Protein kinase Cζ * PKC alpha * PRKCB1 * PRKCD * PRKCE * PRKCH * PRKCG * PRKCI * PRKCQ * Protein kinase N1 * PKN2 * PKN3 Rhodopsin kinase (EC 2.7.11.14)| * Rhodopsin kinase Beta adrenergic receptor kinase (EC 2.7.11.15)| * Beta adrenergic receptor kinase * Beta adrenergic receptor kinase-2 G-protein coupled receptor kinases (EC 2.7.11.16)| * GRK4 * GRK5 * GRK6 Ca2+/calmodulin-dependent (EC 2.7.11.17)| * BRSK2 * CAMK1 * CAMK1A * CAMK1B * CAMK1D * CAMK1G * CAMK2 * CAMK2A * CAMK2B * CAMK2D * CAMK2G * CAMK4 * MLCK * CASK * CHEK1 * CHEK2 * DAPK1 * DAPK2 * DAPK3 * STK11 * MAPKAPK2 * MAPKAPK3 * MAPKAPK5 * MARK1 * MARK2 * MARK3 * MARK4 * MELK * MKNK1 * MKNK2 * NUAK1 * NUAK2 * OBSCN * PASK * PHKG1 * PHKG2 * PIM1 * PIM2 * PKD1 * PRKD2 * PRKD3 * PSKH1 * SNF1LK2 * KIAA0999 * STK40 * SNF1LK * SNRK * SPEG * TSSK2 * Kalirin * TRIB1 * TRIB2 * TRIB3 * TRIO * Titin * DCLK1 Myosin light-chain kinase (EC 2.7.11.18)| * MYLK * MYLK2 * MYLK3 * MYLK4 Phosphorylase kinase (EC 2.7.11.19)| * PHKA1 * PHKA2 * PHKB * PHKG1 * PHKG2 Elongation factor 2 kinase (EC 2.7.11.20)| * EEF2K * STK19 Polo kinase (EC 2.7.11.21)| * PLK1 * PLK2 * PLK3 * PLK4 Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30) | Polo kinase (EC 2.7.11.21)| * PLK1 * PLK2 * PLK3 * PLK4 | Cyclin-dependent kinase (EC 2.7.11.22)| * CDK1 * CDK2 * CDKL2 * CDK3 * CDK4 * CDK5 * CDKL5 * CDK6 * CDK7 * CDK8 * CDK9 * CDK10 * CDK12 * CDC2L5 * PCTK1 * PCTK2 * PCTK3 * PFTK1 * CDC2L1 (RNA-polymerase)-subunit kinase (EC 2.7.11.23)| * RPS6KA5 * RPS6KA4 * P70S6 kinase * P70-S6 Kinase 1 * RPS6KB2 * RPS6KA2 * RPS6KA3 * RPS6KA1 * RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24)| * Extracellular signal-regulated * MAPK1 * MAPK3 * MAPK4 * MAPK6 * MAPK7 * MAPK12 * MAPK15 * C-Jun N-terminal * MAPK8 * MAPK9 * MAPK10 * P38 mitogen-activated protein * MAPK11 * MAPK13 * MAPK14 MAP3K (EC 2.7.11.25)| * MAP kinase kinase kinases * MAP3K1 * MAP3K2 * MAP3K3 * MAP3K4 * MAP3K5 * MAP3K6 * MAP3K7 * MAP3K8 * RAFs * ARAF * BRAF * KSR1 * KSR2 * MLKs * MAP3K12 * MAP3K13 * MAP3K9 * MAP3K10 * MAP3K11 * MAP3K7 * ZAK * CDC7 * MAP3K14 Tau-protein kinase (EC 2.7.11.26)| * TPK1 * TTK * GSK-3 (acetyl-CoA carboxylase) kinase (EC 2.7.11.27)| * - Tropomyosin kinase (EC 2.7.11.28)| * - Low-density-lipoprotein receptor kinase (EC 2.7.11.29)| * - Receptor protein serine/threonine kinase (EC 2.7.11.30)| * Bone morphogenetic protein receptors * BMPR1 * BMPR1A * BMPR1B * BMPR2 * ACVR1 * ACVR1B * ACVR1C * ACVR2A * ACVR2B * ACVRL1 * Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) | MAP2K| * MAP2K1 * MAP2K2 * MAP2K3 * MAP2K4 * MAP2K5 * MAP2K6 * MAP2K7 | * v * t * e Enzymes Activity| * Active site * Binding site * Catalytic triad * Oxyanion hole * Enzyme promiscuity * Catalytically perfect enzyme * Coenzyme * Cofactor * Enzyme catalysis Regulation| * Allosteric regulation * Cooperativity * Enzyme inhibitor * Enzyme activator Classification| * EC number * Enzyme superfamily * Enzyme family * List of enzymes Kinetics| * Enzyme kinetics * Eadie–Hofstee diagram * Hanes–Woolf plot * Lineweaver–Burk plot * Michaelis–Menten kinetics Types| * EC1 Oxidoreductases (list) * EC2 Transferases (list) * EC3 Hydrolases (list) * EC4 Lyases (list) * EC5 Isomerases (list) * EC6 Ligases (list) | This article on a gene on human chromosome 3 is a stub. 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