Protein-coding gene in the species Homo sapiens

PIK3AP1

Identifiers
Aliases| PIK3AP1, BCAP, phosphoinositide-3-kinase adaptor protein 1
External IDs| OMIM: 607942 MGI: 1933177 HomoloGene: 12848 GeneCards: PIK3AP1
| Gene location (Human)

Chr.| Chromosome 10 (human)[1]

Band| 10q24.1| Start| 96,593,315 bp[1]
End| 96,720,514 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 19 (mouse)[2]

Band| 19|19 C3| Start| 41,260,816 bp[2]
End| 41,373,541 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* parotid gland

* pancreatic epithelial cell

* monocyte

* pancreatic ductal cell

* appendix

* blood

* cancellous bone

* bone marrow

* liver

* bone marrow cells

| Top expressed in

* submandibular gland

* spleen

* blood

* Paneth cell

* liver

* right lung lobe

* lymph node

* carotid body

* conjunctival fornix

* left lobe of liver

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* phosphatidylinositol 3-kinase regulatory subunit binding
* identical protein binding
* phosphatidylinositol-4,5-bisphosphate 3-kinase activity
* signaling receptor binding

Cellular component|

* cytoplasm
* cytosol
* plasma membrane
* membrane

Biological process|

* positive regulation of phosphatidylinositol 3-kinase signaling
* toll-like receptor 9 signaling pathway
* toll-like receptor 2 signaling pathway
* toll-like receptor 4 signaling pathway
* toll-like receptor 7 signaling pathway
* regulation of inflammatory response
* phosphatidylinositol phosphate biosynthetic process
* positive regulation of protein kinase B signaling

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

118788

83490

Ensembl| |

ENSG00000155629

ENSMUSG00000025017

UniProt| |

Q6ZUJ8

Q9EQ32

RefSeq (mRNA)| |

NM_152309

NM_031376

RefSeq (protein)| |

NP_689522

NP_113553

Location (UCSC)| Chr 10: 96.59 – 96.72 Mb| Chr 19: 41.26 – 41.37 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene.[5][6][7]

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155629 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025017 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Edwards JA, Sethi PK, Scoma AJ, Bannerman RM, Frohman LA (Apr 1976). "A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance". Am J Med. 60 (1): 23–32. doi:10.1016/0002-9343(76)90529-5. PMID 1251844.
6. ^ Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (Jan 2001). "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation". Immunity. 13 (6): 817–27. doi:10.1016/S1074-7613(00)00079-0. PMID 11163197.
7. ^ "Entrez Gene: PIK3AP1 phosphoinositide-3-kinase adaptor protein 1".

## Further reading[edit]

* Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
* Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
* Maruoka M, Suzuki J, Kawata S, et al. (2005). "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases". FEBS Lett. 579 (14): 2986–90. doi:10.1016/j.febslet.2005.04.052. PMID 15893754. S2CID 20802390.
* Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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