A compilation of 294+ studies showing effectiveness by HCQ is here. See also: Hydroxychloroquine denial See a state-by-state and country-by-country guide of interference with access to HCQ here Hydroxychloroquine, azithromycin (an antibiotic) and zinc has been very effective in treating coronavirus. Hydroxychloroqine (C18H26ClN3O), also known as HCQ, is an inexpensive medication sold under the name Plaquenil.[1] Prior to COVID-19 it was most commonly used to treat malaria, and also currently to treat lupus. American soldiers, such as Lt. Gen. Michael Flynn, have successfully taken this medication for decades as a prophylaxis. The package insert for Plaquenil describes its mostly minor potential side effects,[2] some of which occur only at much higher doses than what is used to treat COVID-19. It has been used by the physician Dr. Vladimir Zelenko as a part of successful treatment for coronavirus and was recommended for such by President Trump who never caught COVID-19 until months after he stopped taking hydroxychloroquine. Specifically, Dr. Zelenko used hydroxychloroqine, azithromycin (an antibiotic) and zinc as a part of his successful treatments to his patients.[3] See Vladimir Zelenko's coronavirus treatment. China, South Korea, and India all use hydroxychloroquine to successfully combat the effects of COVID-19. Italy reversed interference with its use for treating COVID-19 there, and approved its use with this statement: ""The continuing uncertainty about the therapeutic efficacy of hydroxychloroquine, declared by Aifa to justify its continued evaluation, evaluation in randomized clinical trials - is not a sufficient legal reason to justify the unreasonable suspension of its use on the Italian territory by treating physicians."[4] Never-Trumpers in government and hospitals block early use of this medication, and instead either withhold it from patients entirely or delay it until the end stage of the patient's life when medications are least effective. Other governments (such as Texas) initially permitted it only with a positive COVID-19 diagnosis, which delayed patients' access to the medication when it is most effective: early in the progression of the disease, or as a prophylactic. ## Contents * 1 Hydroxychloroquine and coronavirus * 2 Studies * 3 Mechanism * 4 CDC * 5 Zinc and coronavirus * 6 Reduction in binding effect * 7 See also * 8 References * 9 External links ## Hydroxychloroquine and coronavirus[edit] See also: Vladimir Zelenko's coronavirus treatment The Food and Drug Administration (FDA) allows hydroxychloroquine to be used as an off-label coronavirus treatment. According to WebMD.com: "The practice, called 'off-label" prescribing, is entirely legal and very common. More than one in five outpatient prescriptions written in the U.S. are for off-label therapies."[5] In other words, originally approved for use in humans as an anti-malarial drug, it can be prescribed by a treating physician for other uses. Hydroxychloroquine allows zinc to penetrate the cellular wall to a larger degree.[6] Zinc is an antiviral.[7] ## Studies[edit] On May 30, 2020, the Grand Rapids Herald-Review stated: “ | Dr. Vladimir Zelenko serves as a Primary Care Physician in suburban New York City—the epicenter of this outbreak. “I knew that the virus would hit our area hard due to our population density—we have 32,000 people living in one square mile. So I did my own research looking at what had been done in other countries that experienced the virus before us as well as looking at treatments developed for the SARS-CoVid-1 outbreak in 2003 (another coronavirus). I developed my own protocol of a three drug cocktail: HCL, Azithromycin, and Zinc. In the last few weeks I have seen 1,450 patients with COVID symptoms. I divided my patients into two groups: high risk and low risk. The low risk patients (under age 60 and healthy) statistically get better without treatment, so I sent them home to rest and get over the virus. I gave my drug cocktail to 405 high risk patients (over age 60 or with underlying health problems) whose conditions were most severe. The accepted rate of COVID mortality at that time for high risk patients was 5%, so if I had just relied on ventilators I could have expected to see 20 of my patients die. But using these three drugs I only lost two patients, one of which was very old and had been chronically ill. This was a significant order of magnitude better than expected outcomes.” Dr. Zelenko explains the rationale behind his treatment program. “The zinc is what kills the virus and zinc occurs naturally in the body but has a hard time penetrating the cell where the virus lives. What the hydroxychloroquine does is open a channel into the cell so the zinc can enter and stop the virus from replicating. Adding an extra dose of zinc to the cocktail has been shown to improve outcomes by about 25%. Meanwhile, the azithromycin stands guard to combat any secondary bacterial infection that may crash the party and cause pneumonia.” After seeing the effectiveness of his treatment regimen, Dr. Zelenko stated, “I realized what I had, and I felt like a front line soldier who had stumbled across some very important intelligence—some valuable information that needed to be communicated to the 5-star general because that information could be used to win the war.” Within a few weeks, Dr. Zelenko had published video reports of his findings and was in touch not only with the US Coronavirus Taskforce, but with over a dozen governments around the world from Russia, to South Africa, to Peru. Four weeks ago the government of Brazil began implementing Dr. Zelenko’s protocol, and he explains their results: “One week ago the Brazilians published a study revealing a 95% reduction in deaths after this drug cocktail was introduced for use in their government hospitals.”[8] | ” | | "Early Hydroxychloroquine Is Associated with an Increase of Survival," reports a study in Spain on May 5, 2020:[9] Methods: We enrolled all 18-85 years old inpatients from Central Defense Hospital “Gómez Ulla”, Madrid, Spain, who were hospitalised for COVID-19 and had a definitive outcome (dead or discharged). We used a statistical survival analysis to detect treatment differences associated with in-hospital death. Results: We analysed first 220 medical records. 166 patients met the inclusion criteria. 48,8 % of patients not treated with HCQ died, 22% of those treated with hydroxychloroquine (p=0,002). According to clinical picture at admission, hydroxychloroquine increased the mean cumulative survival in all groups from 1,4 to 1,8 times. This difference was statistically significant in the mild group. Conclusions: in a cohort of 166 patients from 18 to 85 years hospitalised with COVID-19, hydroxychloroquine treatment with 800mg added loading dose increased survival when patients were admitted in early stages of the disease. There was a non-statistically significant trend towards survival in all groups, which will have to be clarified in subsequent studies. A study in Mexico reported in September 2020 on success using hydroxychloroquine in hospitalized patients.[10] ## Mechanism[edit] HCQ inhibits the cytokine storm. Professor Raoult of France has suggested additional ways that HCQ helps block COVID-19 replication: 1\. HCQ inhibits the attachment of the amino acid region 111-158 of the viral spike of COVID-19 to gangliosides 2\. The COVID-19 replicative cycle that could be inhibited by HCQ is the pH-dependent viral endocytosis. 3\. Transcription could be impeded by HCQ. 4\. HCQ may block the posttranslational modifications of viral proteins within the endoplasmic reticulum and trans-Golgi network vesicles, perhaps by impairing the maturation of its M protein [113]. 5\. HCQ could be helpful concerning cell-signaling, in particular through MAPK ## CDC[edit] From the CDC:[11] * "Hydroxychloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant women and nursing mothers." * "CDC has no limits on the use of hydroxychloroquine for the prevention of malaria. When hydroxychloroquine is used at higher doses for many years, a rare eye condition called retinopathy has occurred. People who take hydroxychloroquine for more than five years should get regular eye exams." ## Zinc and coronavirus[edit] The usefulness of zinc to HCQ treatments is explained by a study published in September 2020, "Hydroxychloroquine, a drug used initially in the management of COVID-19, is an ionophore that transports Zinc across the hydrophobic cell membrane. Moreover, evidences specifically suggest that Zinc supplemented with antiviral drugs containing Zinc-ionophores precisely targets and binds to SARS-CoV-2 preventing its replication within the infected host cells2."[12] According to the website ResearchGate.net: "Several studies have reported that zinc has a broad-spectrum antiviral activity against a variety of viruses. Increased intracellular Zinc concentrations inhibit RNA-dependent RNA polymerases and other proteins essential for the completion of different phases of the virus life cycle. Further, zinc also helps to maintain robust immune responses by producing cytokine and by modulation of immune cell activity."[13] ## Reduction in binding effect[edit] Hydroxychlorquine reportedly "directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers":[14] > [W]e have provided clear evidence that HCQ can dissociate aPL IgG–β2GPI complexes from phospholipid bilayers. Additional studies will be needed to further define the molecular mechanism(s) for this dissociation and its possible role in modifying the APS disease process. ## See also[edit] * Azithromycin ## References[edit] 1. ↑ Plaquenil Uses, etc. - Drugs.com 2. ↑ https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/009768s037s045s047lbl.pdf 3. ↑ Marchione, Marilynn (March 23, 2020). 'Game changer'? Trump-touted malaria drugs spur hope, shortages. Washington Times. Retrieved March 28, 2020. 4. ↑ http://www.francesoir.fr/politique-monde/italy-council-state-says-yes-hydroxychloroquine-treatment-covid-19 5. ↑ Off-Label Drug Use: What You Need to Know 6. ↑ [1] 7. ↑ Is a combo of chloroquine and Zinc a cure for coronavirus? 8. ↑ Doctors discover effective, life-saving treatment for Covid-19 By Rev. Mark Peske Our Redeemer Lutheran Church, Grand Rapids Herald-Review, May 30, 2020 9. ↑ https://www.preprints.org/manuscript/202005.0057/v1 (emphasis added). 10. ↑ https://www.sciencedirect.com/science/article/pii/S2352906720303365?via=ihub 11. ↑ https://www.cdc.gov/malaria/resources/pdf/fsp/drugs/Hydroxychloroquine.pdf 12. ↑ https://www.sciencedirect.com/science/article/pii/S120197122030730X 13. ↑ Is a combo of chloroquine and Zinc a cure for coronavirus? 14. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518879/ ## External links[edit] * Hydroxychloroquine, Oral Tablet * Hydroxychloroquine - PubChem v • d • e Coronavirus Topics| Azithromycin • Biden border crisis • Blue Plague • Breakthrough case • CARES Act • CCP propaganda war • Contact tracing • Contagious coronavirus • Coronavirus • Coronavirus civil rights • Coronavirus coverup • Coronavirus Survival Guide • Coronavirus studies • Coronavirus bailout • coronavirus incubation period • coronavirus mortality • coronavirus testing • Coronavirus treatments • COVID-19 • Covid claptrap• Covid in children • Covid lockdown • COVID OSHA rules • Covid vaccine • Cytokine storm • Delta variant • Faucism • Flawed coronavirus studies • Freedom Convoy • FTX scandal • Gain of function • Globalism • Global Wuhan coronavirus pandemic • herd immunity • Hospitals blocking hydroxychloroquine • Hydroxychloroquine denial • Liberal misinformation about coronavirus • Long Covid • Media coverage of coronavirus • New Cold War • Nuremberg Code • Omicron variant • Operation Gridlock • Pfizer COVID vaccine • Quinine • Religious exemptions • SARS-CoVid-1 • Scientism • Stay-at-home orders • State restrictions on hydroxychloroquine • Systemic racism • Vaccine passports • Vaccine police • VAERS • War on science • Wolf warrior diplomacy • Wuhan coronavirus - Chinese Communist Party response • Wuhan epidemic coverup • 2020 election fraud Most successful treatments| Hydroxychloroquine • Ivermectin • Vladimir Zelenko's coronavirus treatment • COVID and zinc • COVID-19 and Vitamin D • Zinc • President Trump's treatment for COVID-19 Expensive unproven treatments| Remdesivir • Regeneron • Comirnaty • Paxlovid Profiteers, hucksters and gain-of-function proponents| Big Pharma • Peter Daszak • Anthony Fauci • Bill Gates • Pfizer • Klaus Schwab • Shi Zhengli • Tadros Adhanom • Xi Jinping Public officials| Joe Biden • Andrew Cuomo • Rachel Levine • Phil Murphy • Rochelle Walensky • Gretchen Whitmer • Tom Wolf Organizations| Bill & Melinda Gates Foundation • Chinese Communist Party • Food and Drug Administration • International Criminal Court • Peoples Liberation Army • U.S. Center for Disease Control • World Economic Forum • World Health Organization • Wuhan Institute of Virology Countries| CCP virus in the United States • CCP virus in Canada • pro-euthanasia Belgium • Peoples Republic of China • U.S. funded biological labs abroad Mandates| Biden's vaccine mandate • Covid passport • Lockdown mandate • Mask mandate • Social distancing • Vaccine mandate • Vaccine mandate cases Essays and Books| Pfizer Vaccine Approval Gambit by FDA • Vaxxed Higher Risk of Covid than Unvaxxed • When Government Mandates Become Arbiters of Truth • Ivermectin Given A Fair Hearing to Treat Covid • Vaccine Damage And Deaths Are Becoming Widespread • Monoclonal-Antibody Treatment for COVID-19 • 1905 Supreme Court Ruling Used to Justify Forced Vax • Children as victims of Fauci's Covid restrictions • What the Covid Shot Does to Your Blood: 4 M.D.s speak • Natural Immunity And How It Works • Reminiscent of Nazi Germany: The Disturbing Truth Behind the Vax and Fetal Cell Lines • Dr. Fauci's Cruel Animal Experimentation Revealed: But Is There More? • Orwellian Word Games at CDC On The Word "Vaccine" • Pandemic of the Unvaccinated? • What you should know about (1) Abbott's Home PCR Test Kits and (2) Jabs Causing Attacks Against The Heart • Professor Mattias Desmer Tackles “Mass Formation” (aka Mass Psychosis), Regarding Covid • After Two Years of Fauci Medical Fascism • The Real Anthony Fauci • COVID-19 and the Global Predators: We Are the Prey • Prime Minister Trudeau Compared to Nicolae Ceaușescu • Insurance Companies Register Highest Death Rates Ever • Covid Vaccines for Children Deemed Unnecessary by Experts Court cases| S. 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