Frank Holmes may refer to:

* Sir Frank Holmes (economist) (1924–2011), New Zealand economist
* Frank Holmes (geologist) (1874–1947), British geologist
* Frank E. Holmes, chief executive and chief investment officer at U.S. Global Investors
* Frank Holmes (athlete) (1885–1980), American track and field athlete
* Frank J. Holmes, American painter
* Frank Holmes (filmmaker) (1908–1990), producer and director of Seaport of the Prairies
* Frank Holmes (footballer) (1900–1989), Australian rules footballer
* Frankie Holmes, a co-host and subject of the documentary television series Dopesick Nation

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