## Infective Endocarditis Prophylaxis Regimens [1][edit | edit source]

### Oral Surgery[edit | edit source]

The target of the infective endocarditis prophylaxis is Streptococcus viridans:

| Able to take Oral Medication

Preferred Regimen
▸ Adult:Amoxicillin 2 gm as a single dose 30-60 min before procedure
▸ Pediatrics:Amoxicillin 50 mg/kg as a single dose 30-60 min before procedure
Unable to take Oral Medication

Preferred Regimen'
▸ Adult: Ampicillin 2 g IM or IV as a single dose 30-60 min before procedure
▸ Pediatrics: Ampicillin 50 mg/kg as a single dose 30-60 min before procedure
Alternative Regimen
▸ Adult: Cefazolin or Ceftriaxone 1 g IM or IV as a single dose 30-60 min before procedure
▸ Pedicatrics:Cefazolin or Ceftriaxone 50 mg/kg IM or IV as a single dose 30-60 min before procedure

| Age 1—4 Weeks

Preferred Regimen
▸ Ampicillin 200 mg/kg/day IV q6—8h
AND
▸ Cefotaxime 150—200 mg/kg/day IV q6—8h
Alternative Regimen
▸ Ampicillin 200 mg/kg/day IV q6—8h
AND
▸ Gentamicin 2.5 mg/kg IV q8h

▸Tobramycin 2.5 mg/kg IV q8h

▸ Amikacin 10 mg/kg IV q8h
| Age 1—23 Months

Preferred Regimen
▸ Ampicillin 200 mg/kg/day IV q6—8h
AND
▸ Cefotaxime 150—200 mg/kg/day IV q6—8h
Alternative Regimen
▸ Ampicillin 200 mg/kg/day IV q6—8h
AND
▸ Gentamicin 2.5 mg/kg IV q8h

▸Tobramycin 2.5 mg/kg IV q8h

▸ Amikacin 10 mg/kg IV q8h

## References[edit | edit source]

1. ↑ Wilson W, et al. Circulation 2007;116;1736-1754.