CD38-IN-78c

Identifiers

IUPAC name

* 4-{[(1R,4R)-4-(2-methoxyethoxy)cyclohexyl]amino}-1-methyl-6-(1,3-thiazol-5-yl)quinolin-2-one

CAS Number|

* 1700637-55-3

PubChem CID|

* 118736856

Chemical and physical data
Formula| C22H27N3O3S
Molar mass| 413.54 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC

InChI

* InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3

* Key:VJQALSOBHVEJQM-UHFFFAOYSA-N

CD38-IN-78c is a drug which acts as a potent and selective inhibitor of the glycoprotein enzyme CD38.[1] In animal studies it boosts levels of nicotinamide adenine dinucleotide (NAD+) in tissues via inhibition of CD38 mediated breakdown of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), and has been shown to ameliorate metabolic dysfunction associated with the aging process.[2] It also has potential therapeutic application in the treatment of asthma.[3]

## References

1. ↑ "Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors". Journal of Medicinal Chemistry 58 (8): 3548–71. April 2015. doi:10.1021/jm502009h. PMID 25828863.
2. ↑ "A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline". Cell Metabolism 27 (5): 1081–1095.e10. May 2018. doi:10.1016/j.cmet.2018.03.016. PMID 29719225.
3. ↑ "CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets". Pharmacology & Therapeutics 172: 116–126. 2017. doi:10.1016/j.pharmthera.2016.12.002. PMID 27939939.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/CD38-IN-78c. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:CD38-IN-78c&oldid=767048"
*[CID]: Compound ID