VALUE_ERROR (nil) Identifiers Aliases| External IDs| GeneCards: [1] Orthologs Species| Human| Mouse Entrez| | n/a n/a Ensembl| | n/a n/a UniProt| | n/a n/a RefSeq (mRNA)| | n/a n/a RefSeq (protein)| | n/a n/a Location (UCSC)| n/a| n/a PubMed search| n/a| n/a Wikidata | View/Edit Human| | Solute carrier family 46 (folate transporter), member 1 (SLC46A1) also known as proton-coupled folate transporter (PCFT), is a protein which in humans is encoded by the SLC46A1 gene.[1][2][3] ## Contents * 1 Function * 2 Pathology * 3 References * 4 Further reading * 5 External links ## Function[edit | edit source] SLC46A1 is responsible for the intestinal uptake of folate.[4] ## Pathology[edit | edit source] Mutations of SLC46A1 can cause cerebral folate deficiency. ## References[edit | edit source] 1. ↑ "Entrez Gene: PCFT proton-coupled folate transporter". 2. ↑ Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT (September 2005). "Identification of an intestinal heme transporter". Cell. 122 (5): 789–801. doi:10.1016/j.cell.2005.06.025. PMID 16143108. 3. ↑ Sharma S, Dimasi D, Bröer S, Kumar R, Della NG (April 2007). "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium". Exp. Cell Res. 313 (6): 1251–9. doi:10.1016/j.yexcr.2007.01.019. PMID 17335806. 4. ↑ Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H (August 2007). "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter". J. Pharmacol. Exp. Ther. 322 (2): 469–76. doi:10.1124/jpet.107.122606. PMID 17475902. ## Further reading[edit | edit source] * Subramanian VS, Marchant JS, Said HM (2008). "Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia". Am. J. Physiol., Cell Physiol. 294 (1): C233–40. doi:10.1152/ajpcell.00468.2007. PMID 18003745. * Nakai Y, Inoue K, Abe N, et al. (2007). "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter". J. Pharmacol. Exp. Ther. 322 (2): 469–76. doi:10.1124/jpet.107.122606. PMID 17475902. * Zhao R, Min SH, Qiu A, et al. (2007). "The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption". Blood. 110 (4): 1147–52. doi:10.1182/blood-2007-02-077099. PMC 1939898. PMID 17446347. * Sharma S, Dimasi D, Bröer S, et al. (2007). "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium". Exp. Cell Res. 313 (6): 1251–9. doi:10.1016/j.yexcr.2007.01.019. PMID 17335806. * Latunde-Dada GO, Takeuchi K, Simpson RJ, McKie AT (2007). "Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells". FEBS Lett. 580 (30): 6865–70. doi:10.1016/j.febslet.2006.11.048. PMID 17156779. * Qiu A, Jansen M, Sakaris A, et al. (2007). "Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption". Cell. 127 (5): 917–28. doi:10.1016/j.cell.2006.09.041. PMID 17129779. * Shayeghi M, Latunde-Dada GO, Oakhill JS, et al. (2005). "Identification of an intestinal heme transporter". Cell. 122 (5): 789–801. doi:10.1016/j.cell.2005.06.025. PMID 16143108. * Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. * Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. * Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. * v * t * e Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A) By group SLC1–10 | (1):| * high affinity glutamate and neutral amino-acid transporter * SLC1A1 * 2 * 3 * 4 * 5 * 6 * 7 | (2):| * facilitative GLUT transporter * SLC2A1 * 2 * 3 * 4 * 5 * 6 * 7 * 8 * 9 * 10 * 11 * 12 * 13 * 14 (3):| * heavy subunits of heterodimeric amino-acid transporters * SLC3A1 * 2 (4):| * bicarbonate transporter * SLC4A1 * 2 * 3 * 4 * 5 * 6 * 7 * 8 * 9 * 10 * 11 (5):| * sodium glucose cotransporter * SLC5A1 * 2 * 3 * 4 * 5 * 6 * 7 * 8 * 9 * 10 * 11 * 12 (6):| * sodium\- and chloride\- dependent sodium:neurotransmitter symporters * SLC6A1 * SLC6A2 * SLC6A3 * SLC6A4 * SLC6A5 * SLC6A6 * SLC6A7 * SLC6A8 * SLC6A9 * SLC6A10 * SLC6A11 * SLC6A12 * SLC6A13 * SLC6A14 * SLC6A15 * SLC6A16 * SLC6A17 * SLC6A18 * SLC6A19 * SLC6A20 (7):| * cationic amino-acid transporter/glycoprotein-associated * SLC7A1 * SLC7A2 * SLC7A3 * SLC7A4 * glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters * SLC7A5 * SLC7A6 * SLC7A7 * SLC7A8 * SLC7A9 * SLC7A10 * SLC7A11 * SLC7A13 * SLC7A14 (8):| * Na+/Ca2+ exchanger * SLC8A1 * SLC8A2 * SLC8A3 (9):| * Na+/H+ exchanger * SLC9A1 * SLC9A2 * SLC9A3 * SLC9A4 * SLC9A5 * SLC9A6 * SLC9A7 * SLC9A8 * SLC9A9 * SLC9A10 * SLC9A11 (10):| * sodium bile salt cotransport * SLC10A1 * SLC10A2 * SLC10A3 * SLC10A4 * SLC10A5 * SLC10A6 * SLC10A7 * 10A1 * 10A2 * 10A3 * 10A7 SLC11–20 | (11):| * proton coupled metal ion transporter * SLC11A1 * SLC11A211A3 | (12):| * electroneutral cation-Cl cotransporter * SLC12A1 * SLC12A2 * SLC12A3 * SLC12A4 * SLC12A5 * SLC12A6 * SLC12A7 * SLC12A8 * SLC12A9 (13):| * human Na+-sulfate/carboxylate cotransporter * SLC13A1 * SLC13A2 * SLC13A3 * SLC13A4 * SLC13A5 (14):| * urea transporter * SLC14A1 * SLC14A2 (15):| * proton oligopeptide cotransporter * SLC15A1 * SLC15A2 * SLC15A3 * SLC15A4 (16):| * monocarboxylate transporter * SLC16A1 * SLC16A2 * SLC16A3 * SLC16A4 * SLC16A5 * SLC16A6 * SLC16A7 * SLC16A8 * SLC16A9 * SLC16A10 * SLC16A11 * SLC16A12 * SLC16A13 * SLC16A14 (17):| * Vesicular glutamate transporter 1 * SLC17A1 * SLC17A2 * SLC17A3 * SLC17A4 * SLC17A5 * SLC17A6 * SLC17A7 * SLC17A8 * SLC17A9 (18):| * vesicular monoamine transporter * SLC18A1 * SLC18A2 * SLC18A3 (19):| * folate/thiamine transporter * SLC19A1 * SLC19A2 * SLC19A3 (20):| * type III Na+-phosphate cotransporter * SLC20A1 * SLC20A2 SLC21–30 | (21):| * Organic anion-transporting polypeptide * SLCO1A2 * SLCO1B1 * SLCO1B3 * SLCO1B4 * SLCO1C1 * * SLCO2A1 * SLCO2B1 * * SLCO3A1 * * SLCO4A1 * SLCO4C1 * * SLCO5A1(SLCO6A1) | (22):| * organic cation/anion/zwitterion transporter * SLC22A1 * SLC22A2 * SLC22A3 * SLC22A4 * SLC22A5 * SLC22A6 * SLC22A7 * SLC22A8 * SLC22A9 * SLC22A10 * SLC22A11 * SLC22A12 * SLC22A13 * SLC22A14 * SLC22A15 * SLC22A16 * SLC22A17 * SLC22A18 * SLC22A19 * SLC22A20 (23):| * Na+-dependent ascorbic acid transporter * SLC23A1 * SLC23A2 * SLC23A3 * SLC23A4 (24):| * Na+/(Ca2+-K+) exchanger * SLC24A1 * SLC24A2 * SLC24A3 * SLC24A4 * SLC24A5 * SLC24A6 (25):| * mitochondrial carrier * SLC25A1 * SLC25A2 * SLC25A3 * SLC25A4 * SLC25A5 * SLC25A6 * SLC25A7 * SLC25A8 * SLC25A9 * SLC25A10 * SLC25A11 * SLC25A12 * SLC25A13 * SLC25A14 * SLC25A15 * SLC25A16 * SLC25A17 * SLC25A18 * SLC25A19 * SLC25A20 * SLC25A21 * SLC25A22 * SLC25A23 * SLC25A24 * SLC25A25 * SLC25A26 * SLC25A27 * SLC25A28 * SLC25A29 * SLC25A30 * SLC25A31 * SLC25A32 * SLC25A33 * SLC25A34 * SLC25A35 * SLC25A36 * SLC25A37 * SLC25A38 * SLC25A39 * SLC25A40 * SLC25A41 * SLC25A42 * SLC25A43 * SLC25A44 * SLC25A45 * SLC25A46 (26):| * multifunctional anion exchanger * SLC26A1 * SLC26A2 * SLC26A3 * SLC26A4 * SLC26A5 * SLC26A6 * SLC26A7 * SLC26A8 * SLC26A9 * SLC26A10 * SLC26A11 (27):| * fatty acid transport proteins * SLC27A1 * SLC27A2 * SLC27A3 * SLC27A4 * SLC27A5 * SLC27A6 (28):| * Na+-coupled nucleoside transport (SLC28A1 * SLC28A2 * SLC28A3 (29):| * facilitative nucleoside transporter * SLC29A1 * SLC29A2 * SLC29A3 * SLC29A4 (30):| * zinc efflux * SLC30A1 * SLC30A2 * SLC30A3 * SLC30A4 * SLC30A5 * SLC30A6 * SLC30A7 * SLC30A8 * SLC30A9 * SLC30A10 SLC31–40 | (31):| * copper transporter * SLC31A1 | (32):| * Vesicular glutamate transporter 1 * SLC32A1 (33):| * Acetyl-CoA transporter * SLC33A1 (34):| * type II Na+-phosphate cotransporter * SLC34A1 * SLC34A2 * SLC34A3 (35):| * nucleoside-sugar transporter * SLC35A1 * SLC35A2 * SLC35A3 * SLC35A4 * SLC35A5 * * SLC35B1 * SLC35B2 * SLC35B3 * SLC35B4 * * SLC35C1 * SLC35C2 * * SLC35D1 * SLC35D2 * SLC35D3 * * SLC35E1 * SLC35E2 * SLC35E3 * SLC35E4 (36):| * proton-coupled amino-acid transporter * SLC36A1 * SLC36A2 * SLC36A3 * SLC36A436A2 (37):| * sugar-phosphate/phosphate exchanger * SLC37A1 * SLC37A2 * SLC37A3 * SLC37A4 (38):| * System A & N, sodium-coupled neutral amino-acid transporter * SLC38A1 * SLC38A2 * SLC38A3 * SLC38A4 * SLC38A5 * SLC38A6 * SLC38A10 (39):| * metal ion transporter * SLC39A1 * SLC39A2 * SLC39A3 * SLC39A4 * SLC39A5 * SLC39A6 * SLC39A7 * SLC39A8 * SLC39A9 * SLC39A10 * SLC39A11 * SLC39A12 * SLC39A13 * SLC39A14 (40):| * basolateral iron transporter * SLC40A1 SLC41–48 | (41):| * Magnesium transporter E * SLC41A1 * SLC41A2 * SLC41A3 | (42):| * Ammonia transporter * RhAG * RhBG * RhCG (43):| * Na+-independent, system-L like amino-acid transporter * SLC43A1 * SLC43A2 * SLC43A3 (44):| * Choline-like transporter * SLC44A1 * SLC44A2 * SLC44A3 * SLC44A4 * SLC44A5 (45):| * Putative sugar transporter * SLC45A1 * SLC45A2 * SLC54A3 * SLC45A4 (46):| * Folate transporter * SLC46A1 * SLC46A2 (47):| * multidrug and toxin extrusion * SLC47A1 * SLC47A2 (48):| * Heme transporter SLCO1–4 * O1A2 * O1B1 * O1B3 * O2B1 * O431 * O4A1 Ion pumps | Symporter, Cotransporter| * Na+/K+,Cl− * Na+/Pi3 * Na+/Cl− * Na+/glucose * Na+/I− * Cl−/K+ * 4 * 5 | Antiporter (exchanger)| * Na+/H+ * Na+/Ca2+ * Na+/(Ca2+-K+) - Cl−/HCO− 3 (Band 3) * Cl−-formate * Cl−-oxalate see also solute carrier disorders ## External links[edit | edit source] * GeneReview/NIH/UW entry on Hereditary Folate Malabsorption | This article on a gene on human chromosome 17 is a stub. 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